USP13 Depletion Sensitizes Colorectal Cancer Cells to Necroptosis by Destabilizing cIAP2 Proteins

Investigators described the novel function of ubiquitin-specific protease 13 (USP13) as a crucial regulator of necroptosis. USP13 interacts with cellular IAP2 (cIAP2), stabilizing cIAP2 proteins in colorectal cancer cells.