PARP1-Mediated PARylation of TEAD4 Stabilizes the YAP1-TEAD4 Complex and Promotes Growth and Immune Evasion in Breast Cancer Cells

Investigators found that the poly(ADP-ribose) polymerase PARP1 promotes the transcriptional activity of YAP1-TEAD4 complexes that mediate breast cancer cell stemness, metastatic behavior, and evasion of antitumor immunity.