Site-1 Protease-Mediated Cholesterol Metabolism Is Essential for Lymphatic Development in Mice

Investigators generated mice with pan-endothelial or lymphatic endothelial cells-specific deficiency of either site-1 protease (S1P) or sterol regulatory element-binding proteins 2. Mouse embryos with pan-endothelial deletion of S1P showed defective lymphatic vessel migration in skin and lymphedema, while their blood vasculature formation was relatively normal.