Targeting Circulating Mechanoresponsive Monocytes and Macrophages to Reduce Fibrosis

Investigators identified mechanoresponsive myeloid subpopulations present in scar and unwounded skin. They then modulate these subpopulations by manipulating mechanical strain in vivo and in vitro and find that specifically targeting myeloid mechanical signalling is sufficient to reduce the pro-fibrotic myeloid subpopulations.