N6-Methyladenosine on L1PA Governs the Trans-Silencing of LTRs and Restrains Totipotency in Naive Human Embryonic Stem Cells

Investigators demonstrated that methyltransferase-like 3 deficiency reverts naive hESCs to a totipotent-like state with reactivation and chromatin resetting of 8C-associated genes, eRNAs, and long terminal repeats (LTRs).