3D-Generation of High-Purity Midbrain Dopaminergic Progenitors and Lineage-Guided Refinement of Grafts Supports Parkinson’s Disease Cell Therapy

Investigators developed a three-dimensional differentiation method, SphereDiff, to generate high-purity midbrain dopaminergic (mDA)progenitors, leading to a significant enrichment of mDA neurons post-transplantation.