TGFβ-Activated Kinase-1 Knockdown in Hematopoietic Stem-Progenitor Cells Causes PANoptosis and Myelodysplastic Syndrome-Like Disease in Mice

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Investigators found that TAK1 is required for the survival of hematopoietic stem/progenitor cells by restricting RIPK1 dependent and independent PANoptosis.
[Haematologica]
Abstract