PSMD14-Mediated PFKFB2 Deubiquitination Activates H3K27 Lactylation to Drive Cancer Stemness in Gastric Adenocarcinoma

The authors discovered that highly expressed PSMD14 strengthens tumor stemness and drives tumor progression by increasing glycolysis and lactate accumulation, which activates H3K27 lactylation and turns to enhance the expression of PSMD14 and SOX9.