Mechanical Stretch Prevents Senescence-Associated Osteogenic Impairment in Mesenchymal Stem Cells via CXCR4/PI3K/AKT Signaling

D-galactose–induced premature MSCs were preconditioned with cyclic stretch. The expression levels of CXCR4, senescence markers, and osteogenic markers were assessed and compared with those in young and naturally aged MSCs.