Mechanistic Insights Into Recurrent Implantation Failure: The Lactate-H3K18la-SLC7A11 Axis Explored via Endometrial Organoid and Blastoid-Endometrial Cell Implantation Models

Utilizing human endometrial organoids, researchers demonstrated that lactate enhances human endometrial receptivity by promoting epithelial–mesenchymal transition and upregulating histone H3 lysine 18 lactylation.