Microtubule Dependent Changes in Cell Polarity Are Required for Mammary Epithelial Cell Migration and Branching Morphogenesis

Using organotypic cultures, investigators first examined the organization of the microtubule cytoskeleton. Simple luminal epithelial cells exhibited non-centrosomal, apico-basally oriented microtubule arrays, while stratified luminal cells had centrosomally-radiating microtubules.