Lipid Nanoparticle Library Screen Reveals Lymphatic Endothelial Cell-Targeting Lipid Nanoparticle for Delivering Vascular Endothelial Growth Factor C mRNA after Lymphatic Injury

Researchers identified and validated several lipid nanoparticles (LNP) formulations optimized for high lymphatic endothelial cells uptake when administered Iintradermal and compared their efficacy for delivery of functional mRNA with that of free mRNA and mRNA delivered with a commercially available MC3-based LNP.