Tumor Exosomal Mir-221-3p Induces Glycolysis through the LIFR/GLUT1 Pathway to Destroy the Cerebral Vascular Endothelial Cell Barrier and Promote Breast Cancer Brain Metastasis

Investigators showed that breast cancer can target leukemia inhibitory factor receptor in hCMEC/D3 cells via exosomal miR-221-3p, thereby promoting glycolysis and inhibiting the expression of tight junction proteins, which facilitates tumor metastasis.