Dysregulated Proteostasis in P.A53T-α-Synuclein Astrocytes Aggravates Lewy-Like Neuropathology in a Parkinson’S Disease iPSC Model

By
Jamie Kang
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Researchers differentiated patient-derived p.A53T-αSyn iPSC to ventral midbrain astrocytes and characterized them via comprehensive molecular, functional, and proteomic analyses.
[Proceedings of The National Academy of Sciences of The United States of America]
Abstract