NANOG Governs Cell Metabolism and Redox Homeostasis in Human Naïve Embryonic Stem Cells

Scientists systematically investigated functions of the core transcription factor NANOG in naïve hESCs. Acting as an upstream key regulator, NANOG directly activates genes associated with naïve pluripotency, acetyl-CoA synthesis, and anti-oxidation in a naïve pluripotency state- dependent manner, and represses the expression of extraembryonic lineage genes in naïve hESCs.