Lineage-Specific Enhancer Insertions Regulate Prdm14 to Drive the Rapid Transition from NaïVe to Formative Pluripotency in Rodents

Investigators demonstrated that POU5F1 and TFCP2L1 recognition sequences within Muroidea-specific cis-regulatory elements located downstream of Prdm14 are essential for its transcriptional upregulation in naïve embryonic stem cells