PDGF-BB Inhibits F-Actin Formation and Chondrocyte Dedifferentiation in Osteoarthritis via Oxygen-Dependent HIF-1α/SCIN Regulation and RhoA/ROCK Signaling Inhibition

Scientists investigated the therapeutic potential of platelet-derived growth factor (PDGF)-BB, delivered via sodium hyaluronate, in modulating osteoarthritis chondrocyte microstructure and cytoskeletal dynamics.