Caspase-3 Deficiency Inhibits the Development and Anti-Tumor Response of Bone Marrow-Derived Dendritic Cells

Scientists investigated the impact of Caspase-3 gene deletion on bone marrow-derived dendritic cells (BMDCs) and their anti-tumor functions. BMDCs were generated in vitro using GM-CSF and IL-4 from Caspase-3 knockout and heterozygous mouse progenitors.