Stabilization of FASN by USP5-Mediated Deubiquitination Promotes Hepatocellular Carcinoma Progression

Scientists demonstrated that ubiquitin specific peptidase 5 (USP5) expression is significantly elevated in HCC tissues. The overexpression of USP5 was closely associated with larger tumor sizes, more satellite nodules and tumor emboli, and predicted unfavorable clinical outcome in HCC patients as well.