Anti-uPAR CAR T Cells Reverse and Prevent Aging-Associated Defects in Intestinal Regeneration and Fitness

Scientists have previously identified the urokinase plasminogen activator receptor (uPAR) as a senescence-associated protein and have developed CAR T cells that can efficiently target it. Here, they identified the accumulation of mostly epithelial uPAR-positive cells in the aging gut and uncovered their detrimental impact on intestinal stem cells function in aging.