The Cell Cycle Regulator PLK1 Promotes Murine Melanoma Progression by Regulating the Transcription Factor BACH1

In a melanoma mouse model induced by BRafCA mutation and Pten-deficiency, scientists observed that polo-like kinase 1 (PLK1) overexpression mediated metabolic reprogramming to markedly accelerate tumor growth, promote metastasis, and shorten mice survival.