CD8⁺ T Cell Stemness Precedes Post-Intervention Control of HIV Viremia

Scientists mapped and functionally profiled CD8⁺ T cell responses to autologous HIV epitopes using longitudinal samples from four analytical treatment interruption trials in broadly neutralizing anti-HIV-1 antibody (bNAb) recipients. CD8⁺ T cell stemness was further increased following bNAb administration without the emergence of new clonotypes targeting defined HLA-optimal epitopes.