The Fibroblast Epigenome Underlies SS18::SSX-Mediated Transformation in Synovial Sarcoma

Scientists employed a MSC specific CreERT2 line to express SS18::SSX in fibroblasts and related cell types, resulting in 100% penetrant synovial sarcoma development in mice. Murine tumours exhibited high concordance with human synovial sarcoma subtypes at the histological and molecular levels.