Mechanistic Investigation of FBXW11-Mediated Ubiquitination and Degradation of HIC1 in Regulating IRF1 Transcription and Accelerating Acute Pancreatitis Progression

Scientists elucidated the molecular mechanism by which F-box and WD repeat domain-containing 11 (FBXW11) promotes the progression of acute pancreatitis through ubiquitination-mediated degradation of hypermethylated in cancer 1 (HIC1), thereby enhancing interferon regulatory factor 1 (IRF1) transcription.