RNF187 Neddylation in Pancreatic Cancer Activates Malignancy via IQGAP1-Dependent Actin Cytoskeleton Rearrangement

Investigators focused on screening neddylation-related molecules in pancreatic cancer (PC) and identified RNF187 as a key player, demonstrating its overexpression in PC and its ability to enhance cell proliferation and invasion both in vitro and in vivo.