Cytoskeletal Remodeling via CAMSAP3 Downregulation Drives Resistance to Osimertinib in NSCLC Cells

Researchers found that centrosomal microtubule formation was increased in osimertinib-resistant NSCLC cells, and calmodulin-regulated spectrin-associated protein 3 (CAMSAP3) was identified as the key molecule responsible for the change of microtubule morphology.