Controlled Self-Immolative Release of β-Lapachone via an Optimized -Hydroxybenzyl Linker for Targeted Pancreatic Cancer Therapy

Researchers explored the development of an optimized β-lapachone small molecule prodrug platform that utilizes a β-glucuronide-protected para-hydroxybenzyl moiety alkylated to one of β-lapachone’s carbonyls via an indium-mediated Barbier-type reaction.