Type I and II Interferons Drive Abacavir Hypersensitivity via Treg Suppression and T-Cell Enhancement in Immunocompetent HLA-Transgenic Mice

Scientists highlight the distinct roles of IFN-α and IFN-γ in modulating an immune response against abacavir (APC), with IFN-γ increasing APC activity and IFN-α impairing Treg-mediated regulation in immune competent mice.