CAR T Cells Targeting B7H3 Demonstrate Potent Preclinical Activity against AML and ESCC

Researchers described B7H3-targeted CAR-T cells constructed using the single-chain variable fragment of an anti-B7H3 antibody and systematically evaluated their safety and efficacy in vitro and in mice models of acute myeloid leukemia and esophageal squamous cell carcinoma.