Single-Cell RNA Sequencing Identifies PD-L1 + Mesenchymal Stem Cells with Enhanced Immunomodulatory Capacity and Alleviated the Degree of Ectopic New Bone Formation in Ankylosing Spondylitis

Scientists evaluated the immunomodulatory function of PD-L1-positive mesenchymal stem cells using scRNA-seq and investigated their roles in suppressing inflammation and regulating pathological bone formation in curdlan-induced SKG ankylosing spondylitis mouse models.