NMN-Primed Exosomes Derived from Infrapatellar Fat Pad Mesenchymal Stem Cells Exert Synergistic Anti-Inflammatory and Cartilage-Protective Effects via MERTK Pathway Activation in Knee Osteoarthritis

Investigators evaluated the therapeutic potential of nicotinamide mononucleotide (NMN)–primed exosomes derived from infrapatellar fat pad MSCs, termed Exo^NMN(+), under the hypothesis that NMN priming enhances their anti-inflammatory, antioxidant, and chondroprotective efficacy through MERTK-dependent signaling.