Bone Marrow Failure, Somatic Rescue by P53 Inactivation, and Enhanced Leukemogenesis in Germline ERCC6L2 Disease

Using novel preclinical in vitro and in vivo model systems, investigators demonstrated that excision repair cross-complementing 6 like 2 (ERCC6L2) maintains the competitive fitness of hematopoietic stem and progenitor cells by mitigating replication stress.