IL15/IL15Rα Complex Induces an Antitumor Immune Response Following Radiotherapy Only in the Absence of Tregs and Fails to Expand Progenitor TCF1+ CD8 T Cells

Researchers showed that the combination of radiotherapy and an IL15/IL15Rα fusion complex failed to confer antitumor efficacy; however, a CD8-driven antitumor immune response can be elicited with the concurrent administration of an aCD25 regulatory T cell–depleting antibody.