Targeting SUV4-20H Epigenetic Enzymes Enhances Topoisomerase II Poisoning in Prostate Cancer

By
Emily Salmini
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0
24
Researchers demonstrated that inhibiting histone H4-lysine 20 methyltransferases SUV4-20H1 and SUV4-20H2 induced synthetic lethality in combination with the TOP2 poison etoposide in prostate cancer.
[Cancer Research]
Abstract