IgA-Driven Neutrophil Activation Underlies Severe Dengue Disease after Primary Zika Virus Infection in Humans

Leveraging a long-standing Pediatric Dengue Cohort Study in Nicaragua, researchers showed that anti-NS1 immunoglobulin A antibodies in plasma, elicited after a primary Zika flavivirus infection, drive neutrophil activation and correlate with increased risk of subsequent severe DENV2 disease.