14-3-3ε-Dependent Deubiquitination and Translocation of NLRP3 Activates the Inflammasome during Sepsis

Researchers found that 14-3-3ε facilitates NLRP3 inflammasome activation by enhancing NLRP3 K63 deubiquitination and promoting its translocation to the mitochondria-associated ER membranes for full activation.