Butyrophilin 2A2 Promotes T Cell Immunoregulation via CD45 Phosphatase Activation and Protects against Murine Autoimmune Glomerulonephritis and Pregnancy Loss

The authors identified buytyrophilin 2A2 (BTN2A2) as a modulator of CD45RO signaling in T cells, providing insight into how BTN2A2 regulates T cell-dependent immune responses including those mediating autoimmunity and transplant rejection.