Triple-Remodeling of Tumor Microenvironment through Hyaluronidase-Assisted Folate-Targeted Lipid Nanoparticle-Mediated siVEGF/siPD-L1 for Enhanced Tumor Immunotherapy

Researchers created an efficient combined anti-tumor lipid nanoparticle (LNP) delivery system. They added DMG-PEG2000-FA to the four-component lipid nanoparticle system and used microfluidic technology to prepare FA-LNP with tumor-targeting groups.