Reactive Oligodendrocytes Promote Glioblastoma Progression through CCL5/CCR5-Mediated Glioma Stem Cell Maintenance

Researchers utilized single-cell and spatial transcriptomics from primary and recurrent glioblastoma (GBM) tumors, immunohistochemistry, cytokine profiling, and migration assays to show that GBM cells recruit oligodendrocytes to the tumor border via fractalkine signaling.