FGF12 Induces Aberrant Mechanosignaling in Aortic Smooth Muscle Cells during Thoracic Aortic Aneurysm Formation in Marfan Syndrome Mice

Fibroblast growth factor 12 (FGF12) is markedly upregulated in aortic smooth muscle cells of thoracic aneurysmal aortas from Fbn1^C1039G/+ Marfan syndrome (MFS) mice and from patients with MFS.