NAC and DNase I Synergistically Reduce NETs to Attenuate Severe Acute Pancreatitis via Suppressing the NETs/NF-κB/CXCL3 Pathway

Researchers investigated whether combined N-acetylcysteine (NAC) and deoxyribonuclease I (DNase I) therapy mitigates severe acute pancreatitis and associated lung injury by suppressing neutrophil extracellular traps (NETs) formation and degradation, respectively, and explores the underlying molecular mechanisms.