Astrocytic Noncanonical WNT5B Signaling Modulates Extracellular Matrix Remodeling and Neuropathology in Huntington’S Disease

The noncanonical WNT5B signaling pathway induced sustained expression of matrix metallopeptidase 14 (MMP14), an extracellular matrix (ECM)-degrading enzyme, via activation of the NFATc2 transcription factor in both human and primary mouse astrocytes.