NewslettersESC & iPSC News LDB1 Regulates Gene Expression and Chromatin Structure in Pluripotency and Lineage Differentiation By Noshin Noorjahan - January 28, 2026 0 54 Researchers generated LIM domain-binding 1 (Ldb1)(-/-) ESCs using CRISPR/Cas9 editing and observed a reduction in key stem cell factors SOX2 and KLF4 upon LDB1 loss. [Nucleic Acids Research] Full ArticleGraphical Abstract