The E3 Ligases Itch and WWP2 Regulate Autoimmune Neuroinflammation by Controlling TH2 to TH17 Cell Conversion via Interleukin-4-STAT5 Axis in Mice

The authors showed that the JAK3/STAT5 signaling pathway is critical for maintaining TH2 lineage stability by modulating Blimp1 and c-Maf thereby suppressing TH17 differentiation.