Wnt-Associated DKK3 in Keratinocytes Mediates Radiation-Induced Hyperplasia, Dermatitis, and Skin Fibrosis

To define the function of Dickkopf (DKK) 3 in radiation-induced skin damage, scientists combined complementary in vivo and in vitro approaches, including a 3D human skin model, mice with cell-type-specific Dkk3 deletions, and irradiated human skin specimens.