Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia

By reconstructing epigenetic ontogeny in juvenile myelomonocytic leukemia (JMML), investigators identified a postnatal maturation state of JMML stem cells with high transcriptional plasticity indicative of oncofetal reprogramming in high-risk disease.