Olig2 Acts As an Inducible Barrier to In Vivo Astrocyte-to-Neuron Conversion

Scientists identified Olig2, a basic helix-loop-helix transcription factor, as an inducible barrier to Ngn2-mediated AtN conversion. Olig2 is strongly upregulated in cortical astrocytes following the ectopic expression of bHLH neuronal reprogramming factors.