Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability

Researchers investigated the role of Wnt/β-catenin signaling and its effector, the transcription factor TCF7L2, in postnatal astrocytes using single-nucleus RNA sequencing, imaging, morphometric analysis, microdialysis, and electrophysiology in Tcf7l2 conditional knockout mice.