Fucosyltransferase 8 Facilitates EMT in Glioblastoma Cells through the Remodelling of TGF-β Receptor Core Fucosylation

Scientists demonstrated that fucosyltransferase 8 (FUT8) expression was upregulated in glioblastoma (GBM) compared with low-grade gliomas. FUT8 knockdown inhibited transforming growth factor-β (TGF-β)-induced epithelial–mesenchymal transition (EMT), whereas FUT8 overexpression promoted TGF-β-induced EMT in vitro and in vivo.