A Microneedle Platform Co-Encapsulating Chondral Organoids and PpIX for Spatiotemporally Orchestrated Tumor Ablation and Osteochondral Regeneration

Investigators introduced a spatiotemporal microneedle platform that synergistically combines protoporphyrin IX-mediated sonodynamic therapy for precise tumor eradication with chondral organoid-driven regeneration, leveraging differential mechanical cues for lineage-specific guidance.